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8 Publications visible to you, out of a total of 10
Metabolome plasticity in 241 Arabidopsis thaliana accessions reveals evolutionary cold adaptation processes.

Abstract (Expand)

Acclimation and adaptation of metabolism to a changing environment are key processes for plant survival and reproductive success. In the present study, 241 natural accessions of Arabidopsis (Arabidopsis … thaliana) were grown under two different temperature regimes, 16 degrees C and 6 degrees C, and growth parameters were recorded, together with metabolite profiles, to investigate the natural genome x environment effects on metabolome variation. The plasticity of metabolism, which was captured by metabolic distance measures, varied considerably between accessions. Both relative growth rates and metabolic distances were predictable by the underlying natural genetic variation of accessions. Applying machine learning methods, climatic variables of the original growth habitats were tested for their predictive power of natural metabolic variation among accessions. We found specifically habitat temperature during the first quarter of the year to be the best predictor of the plasticity of primary metabolism, indicating habitat temperature as the causal driver of evolutionary cold adaptation processes. Analyses of epigenome- and genome-wide associations revealed accession-specific differential DNA-methylation levels as potentially linked to the metabolome and identified FUMARASE2 as strongly associated with cold adaptation in Arabidopsis accessions. These findings were supported by calculations of the biochemical Jacobian matrix based on variance and covariance of metabolomics data, which revealed that growth under low temperatures most substantially affects the accession-specific plasticity of fumarate and sugar metabolism. Our findings indicate that the plasticity of metabolic regulation is predictable from the genome and epigenome and driven evolutionarily by Arabidopsis growth habitats.

Authors: J. Weiszmann, D. Walther, P. Clauw, G. Back, J. Gunis, I. Reichardt, S. Koemeda, J. Jez, M. Nordborg, J. Schwarzerova, I. Pierides, T. Nagele, W. Weckwerth

Date Published: 22nd Sep 2023

Publication Type: Journal

Prediction and analysis of redox-sensitive cysteines using machine learning and statistical methods.

Abstract (Expand)

Reactive oxygen species are produced by a number of stimuli and can lead both to irreversible intracellular damage and signaling through reversible post-translational modification. It is unclear which … factors contribute to the sensitivity of cysteines to redox modification. Here, we used statistical and machine learning methods to investigate the influence of different structural and sequence features on the modifiability of cysteines. We found several strong structural predictors for redox modification. Sensitive cysteines tend to be characterized by higher exposure, a lack of secondary structure elements, and a high number of positively charged amino acids in their close environment. Our results indicate that modified cysteines tend to occur close to other post-translational modifications, such as phosphorylated serines. We used these features to create models and predict the presence of redox-modifiable cysteines in human mitochondrial complex I as well as make novel predictions regarding redox-sensitive cysteines in proteins.

Authors: M. Kessler, I. Wittig, J. Ackermann, I. Koch

Date Published: 27th Jul 2021

Publication Type: Journal

Solvent Selection in Homogeneous Catalysis—Optimization of Kinetics and Reaction Performance

Abstract

Not specified

Authors: Fabian Huxoll, Froze Jameel, Jonas Bianga, Thomas Seidensticker, Matthias Stein, Gabriele Sadowski, Dieter Vogt

Date Published: 15th Jan 2021

Publication Type: Journal

Chloroplast-Specific in Vivo Ca 2+ Imaging Using Yellow Cameleon Fluorescent Protein Sensors Reveals Organelle-Autonomous Ca 2+ Signatures in the Stroma

Abstract

Not specified

Authors: Giovanna Loro, Stephan Wagner, Fabrizio Gandolfo Doccula, Smrutisanjita Behera, Stefan Weinl, Joerg Kudla, Markus Schwarzländer, Alex Costa, Michela Zottini

Date Published: 2nd Aug 2016

Publication Type: Journal

A new granulation method for compressed tablets [proceedings].

Abstract

Not specified

Author: M. H. Rubinstein

Date Published: 1st Dec 1976

Publication Type: Journal

Change in the kinetics of sulphacetamide tissue distribution in Walker tumor-bearing rats.

Abstract (Expand)

The effect of Walker tumor on sulphacetamide distribution was studied in rats 21 days after tumor implantation in a hind leg. After oral administration of sulphacetamide (5 and 20 min), the concentration … of the drug was found to be lower in the plasma and liver of tumor-bearing rats when compared with that of control group. However, 90 min after sulphacetamide administration, the concentration of the drug in these same tissues was found to be higher in tumor-bearing rats than in control animals. Whereas the tumor had no apparent effect on sulphacetamide concentration in the brain, drug concentrations in the fat tissue of tumor-bearing rats were constantly higher than those of control animals. These changes in sulphacentamide disposition kinetics could be explained in part by delay in gastrointestinal absorption of the drug. Contrary to what was observed after oral administration, constantly higher drug concentrations were found in the plasma of tumor-bearing rats after iv injection of sulphacetamide. Furthermore, the half-life of sulphacetamide in these same animals was much higher than in control animals. It is concluded that, in Walker tumor-bearing rats, there are changes in the kinetics of sulphacetamide which are functions of the route of administration of the drug.

Authors: D. Nadeau, C. Marchand

Date Published: 1st Nov 1975

Publication Type: Journal

Digitoxin metabolism by rat liver microsomes.

Abstract

Not specified

Authors: A. Schmoldt, H. F. Benthe, G. Haberland

Date Published: 1st Sep 1975

Publication Type: Journal

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