Investigation Pyruvate kinase

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SEEK ID: https://sandbox9.fairdomhub.org/investigations/96

Projects: Workshop FAIRDOMHub / FAIRDOM-SEEK - training course 2024

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Creators and Submitter

Creator

Ulrike W

Submitter

Ulrike W

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Snapshot 1 (26th Nov 2024)

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Created: 26th Nov 2024 at 10:34

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Studies (1)
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Data files (2)
Models (1)
Publications (1)
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Ulrike W

Projects: Training for COST Action OneHealthDrugs, Workshop FAIRDOMHub / FAIRDOM-SEEK - training course 2024

Institutions: Heidelberg Institute for Theoretical Studies

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FAIRDOM-SEEK Training

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Projects: de.NBI Spring School, Tools for Systems biology modeling and data exchange - training course 2023, Workshop FAIRDOMHub / FAIRDOM-SEEK - training course 2024, 2025_FAIRDOM_Training

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Workshop FAIRDOMHub / FAIRDOM-SEEK - training course 2024

FAIRDOM-SEEK Hands-on session

Programme: FAIRDOM-SEEK Training

Public web page: Not specified

Start date: 26th Nov 2024

End date: 26th Nov 2024

Organisms: Bacillus subtilis, Escherichia coli, Lactococcus lactis, Mus musculus, Plasmodium falciparum, Pseudomonas fluorescens, Pseudomonas putida, Rattus norvegicus, Saccharomyces cerevisiae, Sulfolobus solfataricus, Trypanosoma brucei, Homo sapiens, Sylvia atricapilla

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Study PK 1

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Ulrike W

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Submitter: Ulrike W

Investigation: Investigation Pyruvate kinase

Assays: PK 1 experiment pH 7, model glycolysis PK 1

Snapshots: No snapshots

Created: 26th Nov 2024 at 10:37

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PK 1 experiment pH 7

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Ulrike W

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Submitter: Ulrike W

Assay type: Experimental Assay Type

Technology type: Technology Type

Investigation: Investigation Pyruvate kinase

Study: Study PK 1

Organisms: Homo sapiens

SOPs: No SOPs

Data files: PK samples new, data from SABIO-RK 251122024

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Created: 26th Nov 2024 at 10:38, Last updated: 26th Nov 2024 at 11:23

model glycolysis PK 1

Workshop FAIRDOMHub / FAIRDOM-SEEK - training course 2024

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Ulrike W

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Submitter: Ulrike W

Biological problem addressed: Model Analysis Type

Investigation: Investigation Pyruvate kinase

Study: Study PK 1

Organisms: No organisms

Models: glycolysis teusink (biomodels)

SOPs: No SOPs

Data files: No Data files

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Created: 26th Nov 2024 at 11:13, Last updated: 26th Nov 2024 at 11:23

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PK samples new

Workshop FAIRDOMHub / FAIRDOM-SEEK - training course 2024

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Ulrike W

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Creator: Ulrike W

Submitter: Ulrike W

Investigations: Investigation Pyruvate kinase

Studies: Study PK 1

Assays: PK 1 experiment pH 7

Created: 26th Nov 2024 at 10:57

data from SABIO-RK 251122024

Workshop FAIRDOMHub / FAIRDOM-SEEK - training course 2024

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Ulrike W

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Creator: Ulrike W

Submitter: Ulrike W

Investigations: Investigation Pyruvate kinase

Studies: Study PK 1

Assays: PK 1 experiment pH 7

Created: 26th Nov 2024 at 10:50

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glycolysis teusink (biomodels)

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Ulrike W

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Creator: Ulrike W

Submitter: Ulrike W

Model type: Not specified

Model format: SBML

Environment: Not specified

Organism: Not specified

Investigations: Investigation Pyruvate kinase and 1 hidden item

Studies: Study PK 1 and 1 hidden item

Assays: model glycolysis PK 1 and 1 hidden item

Created: 26th Nov 2024 at 11:15, Last updated: 26th Nov 2024 at 11:39

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Pyruvate kinase: Function, regulation and role in cancer.

Workshop FAIRDOMHub / FAIRDOM-SEEK - training course 2024

Abstract (Expand)

Pyruvate kinase is an enzyme that catalyzes the conversion of phosphoenolpyruvate and ADP to pyruvate and ATP in glycolysis and plays a role in regulating cell metabolism. There are four mammalian … pyruvate kinase isoforms with unique tissue expression patterns and regulatory properties. The M2 isoform of pyruvate kinase (PKM2) supports anabolic metabolism and is expressed both in cancer and normal tissue. The enzymatic activity of PKM2 is allosterically regulated by both intracellular signaling pathways and metabolites; PKM2 thus integrates signaling and metabolic inputs to modulate glucose metabolism according to the needs of the cell. Recent advances have increased our understanding of metabolic regulation by pyruvate kinase, raised new questions, and suggested the possibility of non-canonical PKM2 functions to regulate gene expression and cell cycle progression via protein-protein interactions and protein kinase activity. Here we review the structure, function, and regulation of pyruvate kinase and discuss how these properties enable regulation of PKM2 for cell proliferation and tumor growth.

Authors: W. J. Israelsen, M. G. Vander Heiden

Date Published: 17th Aug 2015

Publication Type: Journal

PubMed ID: 26277545

Citation: Semin Cell Dev Biol. 2015 Jul;43:43-51. doi: 10.1016/j.semcdb.2015.08.004. Epub 2015 Aug 13.

Created: 26th Nov 2024 at 10:35

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